Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial.

Motahar Heidari-Beni, Amir R Moravejolahkami, Pegah Gorgian, Gholamreza Askari, Mohammad J Tarrahi, Nimah Bahreini-Esfahani

Journal: Phytotherapy research : PTR 2020;34(8):2067-2073

PMID: 32180294

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Abstract

Osteoarthritis is the most common articular disease that can lead to chronic pain and severe disability. Curcumin-an effective ingredient in turmeric with anti inflammatory property-plays an important role in protecting the joints against destructive factors. Gingerols and piperine, are the effective ingredients of ginger and black pepper, which may potentially enhance and sustain the effect of curcumin in this direction. To determine the effect of cosupplementation with turmeric extract, black pepper, and ginger on prostaglandin E (PGE ) in patients with chronic knee osteoarthritis, compared with Naproxen. Sixty patients with two different levels of knee osteoarthritis (Grade 2 and 3) were studied. Individuals were randomly assigned to receive daily turmeric extract, ginger, and black pepper together or Naproxen capsule for 4 weeks. PGE was evaluated by ELISA method. 24-hr recall was also assessed. All of participants completed the study. PGE decreased significantly in both groups (p < .001), but there was no significant differences between groups. The results of this study indicated that intake of the selected herbs twice a day for 4 weeks may improve the PGE levels in patients with chronic knee osteoarthritis similar to Naproxen drug.

Address: Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.; Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.; Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.; Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.

DOI: 10.1002/ptr.6671

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MeSH Terms: Anti-Inflammatory Agents, Non-Steroidal, Chronic Disease, Curcuma, Curcumin, Double-Blind Method, Female, Zingiber officinale, Humans, Male, Middle Aged, Naproxen, Osteoarthritis, Knee, Piper nigrum, Plant Extracts