State-Dependent Changes in Brain Glycogen Metabolism.

Mauro DiNuzzo, Anne B Walls, Gülin Öz, Elizabeth R Seaquist, Helle S Waagepetersen, Lasse K Bak, Maiken Nedergaard, Arne Schousboe

Journal: Advances in neurobiology 2019;23():269-309

PMID: 31667812

View on PubMed

Abstract

["A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior."]

Address: Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. [email protected].; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.; Department of Medicine, University of Minnesota, Minneapolis, MN, USA.; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY, USA.

DOI: 10.1007/978-3-030-27480-1_9

MeSH Terms: Brain, Energy Metabolism, Glycogen, Neurons