Prevalence of nephropathy in type 1 diabetes in the Arab world: A systematic review and meta-analysis.

Ussama M Abdel-Motal, Akila G, Essam M Abdelalim, Chinnaiyan Ponnuraja, Khadija Iken, Mohamed Jahromi, George Priya Doss, Rajaa El Bekay, Hatem Zayed

Journal: Diabetes/metabolism research and reviews 2019;34(7):e3026

PMID: 29774648

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Abstract

The aim of this study was to conduct a systematic review and meta-analysis and determine the prevalence of diabetic nephropathy (DN) among Arab patients with T1D. A systematic literature search was conducted using 4 different literature databases (PubMed, ScienceDirect, Web of Science, and Embase) to capture all relevant data about Arab patients with T1D that had DN. Meta-analysis and systematic review were performed using the random effect model, and the heterogeneity of the studies was assessed using the Q-test, I2, and Tau-squared statistics. Publication bias was assessed using the funnel-plot test. Our search strategy captured 372 studies in only 10 out of the 22 Arab countries in a period of 48 years (1969-2017); of which, 41 met our inclusion criteria for full article analysis, of those, 15 were eligible for meta-analysis. We estimated the prevalence of DN among Arab people with T1D to be 18.2% (95% confidence interval 13.1%-24.8%). In conclusion, DN prevalence is underexplored among Arab patients with T1D and represents a significant risk for the well-being of Arab patients with T1D. Therefore, there is an urgent need for comprehensive epidemiological studies for DN among Arab patients with T1D.

Address: Division of Translational Medicine, Research Branch, Sidra Medicine, Doha, Qatar.; Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar.; Diabetes Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.; Department of Statistics, National Institute for Research in Tuberculosis, Chennai, India.; Department of Medicine/Paediatrics', Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Dasman Diabetes Institute, Dasman, Kuwait.; Department of Integrative Biology, School of Biosciences and Technology, VIT University, Vellore, India.; CIBER Pathophysiology of obesity and nutrition CB06/03, Carlos III Health Institute. Unidad de Gestion Clínica Intercentros de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga/Universidad de Málaga, Málaga, Spain.

DOI: 10.1002/dmrr.3026