Fetal membrane architecture, aging and inflammation in pregnancy and parturition.

Ramkumar Menon, Lauren S Richardson, Martha Lappas

Journal: Placenta 2020;79():40-45

PMID: 30454905

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Abstract

Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of preterm premature rupture of the fetal membranes (pPROM). Thus, increased knowledge of the structure characteristics of fetal membranes as well as the mechanisms of membrane rupture are essential if we are to develop effective treatment strategies to prevent pPROM. In this review, we focus on the role of inflammation and senescence in fetal membrane biology.

Address: Division of Maternal-Fetal Medicine & Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA. Electronic address: [email protected].; Division of Maternal-Fetal Medicine & Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.; Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia. Electronic address: [email protected].

DOI: 10.1016/j.placenta.2018.11.003

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MeSH Terms: Cellular Senescence, Extraembryonic Membranes, Female, Humans, Inflammation, Pregnancy, Premature Birth, Term Birth