Heritable traits that contribute to nephrolithiasis.

John C Lieske, Xiangling Wang

Journal: Urolithiasis 2019;47(1):5-10

PMID: 30460525

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Abstract

Urinary stones tend to cluster in families. Of the known risk factors, evidence is strongest for heritability of urinary calcium excretion. Recent studies suggest that other stone risk factors may have heritable components including urinary pH, citrate and magnesium excretion, and circulating vitamin D concentration. Several risk factors assumed purely environmental may also have heritable components, including dietary intake and thirst. Thus, future studies may reveal that genetics plays an even stronger role in urinary stone pathogenesis than previously known.

Address: Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55901, USA. [email protected].; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. [email protected].; Genomic Medicine Institute, Department of Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

DOI: 10.1007/s00240-018-1095-1

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https://dx.doi.org/10.1007/s00240-018-1095-1

MeSH Terms: Citrates, Feeding Behavior, Genetic Predisposition to Disease, Humans, Kidney, Kidney Calculi, Magnesium, Renal Elimination, Risk Factors, Vitamin D