Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer.

Şükrü Tüzmen, Galen Hostetter, Aprill Watanabe, Cumhur Ekmekçi, Patricia E Carrigan, Ishaiahu Shechter, Olli Kallioniemi, Laurence J Miller, Spyro Mousses

Journal: Personalized medicine 2019;16(1):51-65

PMID: 30468409

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Abstract

To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. This cellular compartment can be expanded by acquisition of cholesterol from the circulation or by its synthesis in a metabolic pathway regulated by the FDFT1 enzyme. Given the critical role this might play in carcinogenesis and in the behavior of cancers, we have examined the level of this enzyme in various types of human cancer. Our demonstration of elevated levels of FDFT1 mRNA and protein in some tumors relative to surrounding normal tissue identifies this as a possible biomarker for disease development and progression, and as a potential new target for the treatment of cancer.

Address: Department of Biological Sciences, Molecular Biology & Genetics Program, Faculty of Arts & Sciences, Eastern Mediterranean University (EMU), Famagusta, North Cyprus via Mersin 10, 99628, Turkey.; Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.; Van Andel Research Institute, Grand Rapids, MI 49503, USA.; Cigna Medical Group, Texas Tech University, Phoenix, AZ, USA.; Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey.; Cancer Center & Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, 13400 E. Shea Blvd, Scottsdale, AZ 85259, USA.; Bayer HealthCare, Berlin, Germany.; Department of Surgery, School of Medicine, Uniformed Services University, Bethesda, MD 20814, USA.; Medical Biotechnology Center, VTT Technical Research Centre of Finland & University of Turku, Turku, Finland.; Systems Oncology, Scottsdale, AZ 85260, USA.

DOI: 10.2217/pme-2016-0058

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MeSH Terms: Biomarkers, Tumor, Carcinogenesis, Cell Cycle, Cell Line, Tumor, Cell Proliferation, Cholesterol, DNA Methylation, Disease Progression, Farnesyl-Diphosphate Farnesyltransferase, Genomics, Humans, Membrane Microdomains, Neoplasms, Polyisoprenyl Phosphates, Proteomics, RNA, Messenger, Sesquiterpenes, Tissue Array Analysis, Transcriptome