High-Density Lipoprotein Components and Functionality in Cancer: State-of-the-Art.

Shiva Ganjali, Biagio Ricciuti, Matteo Pirro, Alexandra E Butler, Stephen L Atkin, Maciej Banach, Amirhossein Sahebkar

Journal: Trends in endocrinology and metabolism: TEM 2019;30(1):12-24

PMID: 30473465

Full Text on Elsevier Science View on PubMed

Abstract

Cancer is the second leading cause of death in western countries, and thus represents a major global public health issue. Whilst it is well-recognized that diet, obesity, and smoking are risk factors for cancer, the role of low levels of high-density lipoprotein cholesterol (HDL-C) in cancer is less well appreciated. Conflicting evidence suggests that serum HDL-C levels may be either positively or negatively associated with cancer incidence and mortality. Such disparate associations are supported in part by the multitude of high-density lipoprotein (HDL) functions that can all have an impact on cancer cell biology. The aim of this review is to provide a comprehensive overview of the crosstalk between HDLs and cancer, focusing on the molecular mechanisms underlying this association.

Address: Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Oncology, S. Maria della Misericordia Hospital, Perugia, Italy.; Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy.; Diabetes Research Center, Qatar Biomedical Research Institute, Doha, Qatar.; Weill Cornell Medical College, New York, NY, USA.; Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected].

DOI: 10.1016/j.tem.2018.10.004

Link outs

Free resources

Medical:

https://medlineplus.gov/hdlthegoodcholesterol.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-SNCG-3

Subscription / membership required

Full Text Sources:

MeSH Terms: ATP Binding Cassette Transporter 1, Cholesterol, HDL, Humans, Lipoproteins, HDL, Neoplasms