Update on opsoclonus-myoclonus syndrome in adults.

Sun-Young Oh, Ji-Soo Kim, Marianne Dieterich

Journal: Journal of neurology 2019;266(6):1541-1548

PMID: 30483882

Abstract

Opsoclonus-myoclonus syndrome in adults is a rare and heterogeneous disorder with the clinical features of opsoclonus, myoclonus, ataxia, and behavioral and sleep disturbances. The pathophysiology is thought to be immunological on the basis of paraneoplastic or infectious etiologies. Immunomodulatory therapies should be performed although the response may be incomplete. A number of autoantibodies have been identified against a variety of antigens, but no diagnostic immunological marker has yet been identified. This review focuses on underlying mechanisms of opsoclonus-myoclonus syndrome, including findings that have been identified recently, and provides an update on the clinical features and treatments of this condition.

Address: Department of Neurology, Chonbuk National University School of Medicine, 20 Geonji-ro, Deokjin-gu, Jeonju, Chonbuk, 561-712, South Korea. [email protected].; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, South Korea. [email protected].; Department of Neurology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Neurology, Dizziness Center, Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, South Korea.; Department of Neurology, Ludwig-Maximilians-University, Munich, Germany.; German Center for Vertigo and Balance Disorders (IFBLMU), Ludwig-Maximilians University, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

DOI: 10.1007/s00415-018-9138-7

Link outs

Subscription / membership required

Full Text Sources:

https://dx.doi.org/10.1007/s00415-018-9138-7

MeSH Terms: Adult, Humans, Opsoclonus-Myoclonus Syndrome