Skeletal Morbidity in Children and Adolescents during and following Cancer Therapy.

Sogol Mostoufi-Moab, Leanne M Ward

Journal: Hormone research in paediatrics 2019;91(2):137-151

PMID: 30481777

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Abstract

Skeletal abnormalities are common in children and adolescents diagnosed and treated for a malignancy. The spectrum ranges from mild pain to debilitating osteonecrosis and fractures. In this review, we summarize the impact of cancer therapy on the developing skeleton, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life in childhood cancer survivors.

Address: Department of Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA, [email protected].; Department of Pediatrics, The Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.

DOI: 10.1159/000494809

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MeSH Terms: Adolescent, Cancer Survivors, Child, Child, Preschool, Female, Fractures, Bone, Humans, Male, Musculoskeletal Development, Neoplasms, Osteonecrosis, Quality of Life