Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia.

Cande V Ananth, Kathleen Jablonski, Leslie Myatt, James M Roberts, Alan T N Tita, Kenneth J Leveno, Uma M Reddy, Michael W Varner, John M Thorp, Brian M Mercer, Alan M Peaceman, Susan M Ramin, Marshall W Carpenter, Philip Samuels, Anthony Sciscione, Jorge E Tolosa, George Saade, Yoram Sorokin

Journal: American journal of perinatology 2020;36(6):624-631

PMID: 30282103

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Abstract

OBJECTIVE

To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s).

STUDY DESIGN

We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions.

RESULTS

Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% ( = 5,374) on all three family members, 26.5% ( = 2,562) in mother and sister(s) only, and 11.6% ( = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00-1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12-2.13) and 1.35 (95% CI: 1.03-1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption.

CONCLUSION

This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.

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Address: Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Joseph L. Mailman School of Public Health, Columbia University, New York, New York.; Department of Health Policy and Management, Joseph L. Mailman School of Public Health, Columbia University, New York, New York.; Department of Obstetrics and Gynecology, Biostatistics Center, The George Washington University, Washington, District of Columbia.; Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio.; Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.; Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas.; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah.; Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Obstetrics and Gynecology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.; Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.; Department of Obstetrics and Gynecology, Children's Memorial Hermann Hospital, The University of Texas Health Science Center at Houston, Houston, Texas.; Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island.; Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio.; Department of Obstetrics and Gynecology, Drexel University, Philadelphia, Pennsylvania.; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon.; Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas.; Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan.

DOI: 10.1055/s-0038-1672177

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MeSH Terms: Abruptio Placentae, Adult, Female, Humans, Infant, Newborn, Infant, Small for Gestational Age, Ischemia, Male, Placenta, Placenta Diseases, Pre-Eclampsia, Pregnancy, Randomized Controlled Trials as Topic, Young Adult