Isolevuglandins and cardiovascular disease.

Sean S Davies, Linda S May-Zhang

Journal: Prostaglandins & other lipid mediators 2019;139():29-35

PMID: 30296489

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Abstract

Isolevuglandins are 4-ketoaldehydes formed by peroxidation of arachidonic acid. Isolevuglandins react rapidly with primary amines including the lysyl residues of proteins to form irreversible covalent modifications. This review highlights evidence for the potential role of isolevuglandin modification in the disease processes, especially atherosclerosis, and some of the tools including small molecule dicarbonyl scavengers utilized to assess their contributions to disease.

Address: Department of Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States. Electronic address: [email protected].; Department of Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States.

DOI: 10.1016/j.prostaglandins.2018.10.002

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MeSH Terms: Arachidonic Acid, Atherosclerosis, Cardiovascular Diseases, Humans, Lipid Peroxidation, Lipids