Vasoproliferative retinopathy secondary to Waldenström's disease.

G Espinosa-Barberi, F J Galván González, S Miranda Fernández, D Viera Peláez, F Medina Rivero, D Marrero Saavedra

Journal: Archivos de la Sociedad Espanola de Oftalmologia 2019;94(2):85-89

PMID: 30318175

Full Text on Elsevier Science View on PubMed

Abstract

A 66 year-old patient, monitored for diabetic retinopathy refractory to multiple treatment methods despite a good metabolic control, referred to progressive weight loss. For this reason, a systemic study was performed, detecting anaemia, elevation of the erythrocyte sedimentation rate, and hyperproteinaemia due to elevated serum levels of monoclonal IgM. Subsequently, by performing a bone marrow biopsy and genetic study, the diagnosis of Waldenström macroglobulinaemia was made. Waldenström's macroglobulinaemia is a low frequency lymphoproliferative disease, for which the main manifestation is a hyperviscosity syndrome that can produce ophthalmological signs detectable by funduscopy and imaging tests. A multimodal study is useful in the diagnosis and monitoring of retinal involvement. The incorporation of angiography by optical coherence tomography allows a more precise study of the microvascular disorders that may occur at the posterior pole level.

Address: Servicio de Oftalmología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España; Escuela de Doctorado y Posgrado, Universidad Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, España. Electronic address: [email protected].; Servicio de Oftalmología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España.

DOI: 10.1016/j.oftal.2018.09.006

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MeSH Terms: Aged, Angiogenesis Inhibitors, Diabetes Mellitus, Type 2, Diabetic Retinopathy, Humans, Immunoglobulin M, Male, Ophthalmoscopy, Paraproteins, Ranibizumab, Retinal Neovascularization, Tomography, Optical Coherence, Waldenstrom Macroglobulinemia