Biomimetic cofactors and methods for their recycling.

Ioannis Zachos, Claudia Nowak, Volker Sieber

Journal: Current opinion in chemical biology 2019;49():59-66

PMID: 30336443

Full Text on Elsevier Science View on PubMed

Abstract

Nicotinamide cofactor biomimetics (NCBs) belong to a class of compounds that, as the name suggests, mimic the structures and functions of natural nicotinamide cofactors, namely nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate and their corresponding reduced forms. The first set of NCBs was discovered in the 1930s; these were initially used to study the chemical properties of this class of cofactors as well as understand nicotinamide binding of oxidoreductases. Since then, various NCBs, enzymes, and recycling systems have evolved and lately, new NCBs have been developed and used to run biocatalytic reactions.

Address: Chair of Chemistry of Biogenic Resources, Technical University of Munich, Campus Straubing for Biotechnology and Sustainability, Schulgasse 16, 94315 Straubing, Germany.; Chair of Chemistry of Biogenic Resources, Technical University of Munich, Campus Straubing for Biotechnology and Sustainability, Schulgasse 16, 94315 Straubing, Germany; Current address: Dr. Ebeling & Assoc. GmbH, Hamburg, Germany.; Chair of Chemistry of Biogenic Resources, Technical University of Munich, Campus Straubing for Biotechnology and Sustainability, Schulgasse 16, 94315 Straubing, Germany; Catalysis Research Center, Technical University of Munich, Garching, Germany; Fraunhofer Institute of InterfacialBiotechnology (IGB), Bio-, Electro- and Chemo Catalysis (BioCat) Branch, Straubing, Germany; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Qld, Australia. Electronic address: [email protected].

DOI: 10.1016/j.cbpa.2018.10.003

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MeSH Terms: Biocatalysis, Biomimetics, NAD, Niacinamide