Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis.

J Enrique Dominguez-Munoz, Asbjørn M Drewes, Björn Lindkvist, Nils Ewald, László Czakó, Jonas Rosendahl, J Matthias Löhr

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2019;18(8):847-854

PMID: 30344091

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

In collaboration with United European Gastroenterology, the working group on 'Harmonizing diagnosis and treatment of chronic pancreatitis across Europe' (HaPanEU) developed European guidelines for the management of chronic pancreatitis using an evidence-based approach.

METHODS

Recommendations of multidisciplinary review groups based on systematic literature reviews to answer predefined clinical questions are summarised. Recommendations are graded using the Grading of Recommendations Assessment, Development and Evaluation system.

RESULTS

Recommendations covered topics related to the clinical management of chronic pancreatitis: aetiology, diagnosis of chronic pancreatitis with imaging, diagnosis of pancreatic exocrine insufficiency, surgical therapy, medical therapy, endoscopic therapy, treatment of pancreatic pseudocysts, pancreatic pain, nutrition and malnutrition, diabetes mellitus and the natural course of the disease and quality of life.

CONCLUSIONS

The HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research. This article summarises the HaPanEU recommendations and statements.

Address: Department of Gastroenterology and Hepatology, Health Research Institute, University Hospital of Santiago de Compostela, Spain. Electronic address: [email protected].; Centre for Pancreatic Diseases, Department of Gastroenterology, Aalborg University Hospital, Denmark.; Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Internal Medicine, General Hospital Luebbecke-Rahden, Luebbecke, Justus Liebig University Giessen, Giessen, Germany.; First Department of Medicine, University of Szeged, Szeged, Hungary.; Department of Internal Medicine I, Martin Luther University, Halle (Saale), Germany.; Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

DOI: 10.1016/j.pan.2018.09.016

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MeSH Terms: Endoscopy, Evidence-Based Medicine, Exocrine Pancreatic Insufficiency, Humans, Pain, Pain Management, Pancreatic Pseudocyst, Pancreatitis, Chronic