Apolipoprotein A-IV: A potential therapeutic target for atherosclerosis.

Jia Peng, Xiang-Ping Li

Journal: Prostaglandins & other lipid mediators 2019;139():87-92

PMID: 30352313

Full Text on Elsevier Science View on PubMed

Abstract

Apolipoprotein A-IV is lipid-binding protein, which is synthesized by the intestine and secreted into mesenteric lymph. ApoA-IV is correlated with chylomicrons and high density lipoprotein, but a large portion is free-lipoprotein, in circulation. Studies showed that apoA-IV has anti-inflammatory and anti-oxidative properties, and is able to mediate reverse cholesterol transport, which suggest that it may has anti-atherosclerotic effects and be related to protection from atherosclerotic cardiovascular disease. This article focus on current studies and the possible anti-atherogenic mechanism related to apoA-IV, in order to provide a new therapeutic target for atherosclerotic cardiovascular diseases.

Address: Department of Cardiovascular Diseases, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan, 410011, China.; Department of Cardiovascular Diseases, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan, 410011, China. Electronic address: [email protected].

DOI: 10.1016/j.prostaglandins.2018.10.004

Link outs

Free resources

Medical:

https://medlineplus.gov/atherosclerosis.html

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S1098...

MeSH Terms: Apolipoproteins A, Atherosclerosis, Cholesterol, Humans, Intestinal Mucosa, Lipid Metabolism, Lipoproteins, HDL, Protein Binding, Protein Transport