The use of proteomic technologies to study molecular mechanisms of multidrug resistance in cancer.

Yi Cao, Ziyin Li, Lianzhi Mao, Hehe Cao, Jingjing Kong, Bin Yu, Changmin Yu, Wenzhen Liao

Journal: European journal of medicinal chemistry 2019;162():423-434

PMID: 30453249

Full Text on Elsevier Science View on PubMed

Abstract

Multidrug resistance (MDR), defined as the cross-resistance of cancer cells toward a broad range of chemotherapeutic agents, is a universal and intractable problem in chemotherapy. The understanding of MDR mechanisms is essential to discover the potential biomarkers for predicting multidrug resistance and more importantly, tackling and preventing multidrug resistance. Multiple technologies have been used to study MDR mechanisms including comparative genomic hybridization, DNA array, differential display RT-PCR and various immunoassays. Compared with these approaches, proteomic technologies allow a high through-put analysis of protein detection, protein quantification and protein interaction with high accuracy. With the rapid development of proteomic studies in recent years, proteomic technologies have made substantial contributions to the characterization of MDR mechanisms including MDR-related protein detection and quantification, as well as the characterization of drug-transporter binding sites. This review offers a comprehensive illustration of MDR, proteomic technologies and the discoveries made in understanding MDR mechanisms using proteomic approaches.

Address: Key Laboratory of Environment-Friendly Chemistry and Application of Ministry of Education, Lab of Biochemistry, College of Chemistry, Xiangtan University, Xiangtan, 411105, China.; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (Nanjing Tech), Nanjing, 211816, China. Electronic address: [email protected].; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China. Electronic address: [email protected].

DOI: 10.1016/j.ejmech.2018.10.001

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MeSH Terms: Drug Resistance, Multiple, Drug Resistance, Neoplasm, Humans, Neoplasms, Proteomics