The effect of an oral ginger supplementation on NF-κB concentration in peripheral blood mononuclear cells and anthropomorphic data of patients with type 2 diabetes: A randomized double-blind, placebo-controlled clinical trial.

Niyaz Mohammadzadeh Honarvar, Meysam Zarezadeh, Masoud Khorshidi, Motahareh Makhdoomi Arzati, Mir Saeed Yekaninejad, Mina Abdollahi, Mohammad Effatpanah, Rezvan Hashemi, Ahmad Saedisomeolia

Journal: Complementary therapies in medicine 2019;42():7-11

PMID: 30670285

Full Text on Elsevier Science View on PubMed

Abstract

INTRODUCTION

The complications of diabetes are extensive which can be caused by excessive oxidative stress, inflammation and impaired insulin system. Plant-sourced bioactive compounds can reduce inflammation and oxidative stress. The aim of present study was to determine the effect of ginger supplementation on diabetic complications.

METHODS

The present study is a randomized double blind clinical trial which is conducted with 48 diabetic patients. The participants were randomly divided into two intervention and placebo groups which were received 2 g ginger powder and 2 g wheat flour respectively for 10 weeks. Nuclear factor kappa B (NF-κB) concentration and anthropometric measurements were evaluated at the baseline and at the end of study.

RESULTS

The effect of ginger supplementation on hip circumference was marginal and there was no significant effect on BMI and waist circumference. Mean NF-κB p65 concentrations were reduced in ginger supplementation group, however, the amount was not statistically significant.

CONCLUSION

Ginger supplementation had significant effects on anthropometric evaluations. Ginger supplementation decreased mean NF-κB concentration in comparison with placebo, however the significance level was marginal. In order to achieve reliable information, more researches should be complemented with uptake of other diagnostic tools.

Address: Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Biostatistics and Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; AmirAlam Hospital Complex, Marvasti Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; School of Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Geriatric Medicine, Ziaeian Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

DOI: 10.1016/j.ctim.2018.10.019

Link outs

Free resources

Medical:

https://medlineplus.gov/diabetestype2.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Diabetes Mellitus, Type 2, Dietary Supplements, Double-Blind Method, Female, Zingiber officinale, Humans, Inflammation, Leukocytes, Mononuclear, Male, Middle Aged, NF-kappa B, Plant Extracts, Transcription Factor RelA, Waist Circumference