A meta-analysis of Italian and Estonian individuals shows an effect of common variants in on blood apoB levels.

Martina Rosticci, Natalia Pervjakova, Marika Kaakinen, Arrigo F Cicero, Arne P Feufer, Letizia Marullo, Reedik Mägi, Krista Fischer, Longda Jiang, Sergio D'Addato, Elisabetta Rizzoli, Gianmichele Massimo, Marina Giovannini, Sabrina Angelini, Patrizia Hrelia, Chiara Scapoli, Claudio Borghi, Inga Prokopenko

Journal: Biomarkers in medicine 2020;13(11):931-940

PMID: 30191727

Abstract

The aim of the study was to explore the effects of variants at on a range of cardio-metabolic phenotypes. We analyzed the range of variants within Genetics in Brisighella Health Study and genes using an additive genetic model on 18 cardiometabolic phenotypes in a sample of 1645 individuals from the Genetics in Brisighella Health Study and replicated in 10,662 individuals from the Estonian Genome Center University of Tartu. We defined directly the effects of rs3846662:C>A at on apoB levels. The analysis also confirmed effects of on low-density lipoprotein-cholesterol and total cholesterol levels. Variants in gene did not reveal any associations with cardiometabolic phenotypes. This study highlights effect of locus on assay-determined apoB levels, an infrequent measure of blood lipids in large studies.

Address: Medicine & Surgery Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Department of Biotechnology, Institute of Molecular & Cell Biology, University of Tartu, Tartu, Estonia.; Genomics of Common Disease, Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Imperial College London, London, UK.; Genomics of Common Disease, Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Imperial College London, London, UK.; Pharmacology & Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK.; Institute of Bioinformatics & Systems Biology, Helmholtz Zentrum München, München, Germany.; Department of Life Sciences & Biotechnology, University of Ferrara, Ferrara, Italy.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Genomics of Common Disease, Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Imperial College London, London, UK.; Department of Pharmacy & Biotechnology, Alma Mater Studiorum University of Bologna, Italy.
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