Dyslipidemias in clinical practice.

Manuel Castro Cabezas, Benjamin Burggraaf, Boudewijn Klop

Journal: Clinica chimica acta; international journal of clinical chemistry 2019;487():117-125

PMID: 30201369

Full Text on Elsevier Science View on PubMed

Abstract

Most dyslipidemic conditions have been linked to an increased risk of cardiovascular disease. Over the past few years major advances have been made regarding the genetic and metabolic basis of dyslipidemias. Detailed characterization of the genetic basis of familial lipid disorders and knowledge concerning the effects of environmental factors on the expression of dyslipidemias have increased substantially, contributing to a better diagnosis in individual patients. In addition to these developments, therapeutic options to lower cholesterol levels in clinical practice have expanded even further in patients with familial hypercholesterolemia and in subjects with cardiovascular disease. Finally, promising upcoming therapeutic lipid lowering strategies will be reviewed. All these advances will be discussed in relation to current clinical practice with special focus on common lipid disorders including familial dyslipidemias.

Address: Department of Internal Medicine, Franciscus Gasthuis & Vlietland, Kleiweg 500, 3045 PM Rotterdam, the Netherlands.; Department of Internal Medicine, Franciscus Gasthuis & Vlietland, Kleiweg 500, 3045 PM Rotterdam, the Netherlands; Department of Cardiology, Erasmus MC, 's Gravendijkwal 230, 3015 CE Rotterdam, the Netherlands. Electronic address: [email protected].

DOI: 10.1016/j.cca.2018.09.010