Carnosine Supplementation Improves Serum Resistin Concentrations in Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial.

Estifanos Baye, Jozef Ukropec, Maximilian P J de Courten, Aya Mousa, Timea Kurdiova, Josphin Johnson, Kirsty Wilson, Magdalena Plebanski, Giancarlo Aldini, Barbara Ukropcova, Barbora de Courten

Journal: Nutrients 2018;10(9):1258

PMID: 30205427

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Abstract

Adipokines play an important role in the regulation of glucose metabolism. We have previously shown that carnosine supplementation in overweight or obese non-diabetic individuals improves glucose metabolism but does not change adiponectin concentrations. However, its effect on other adipokines has not been investigated. Herein we further determined the effect of carnosine supplementation on serum adipsin, resistin and leptin. Twenty-two overweight or obese otherwise healthy adults were randomly assigned to receive either 2 g of carnosine ( = 13) or identically looking placebo ( = 9) for 12 weeks. Serum adipsin, leptin and resistin were analyzed using a bead-based multiplex assay. Carnosine supplementation decreased serum resistin concentrations compared to placebo (mean change from baseline: -35 ± 83 carnosine vs. 35 ± 55 ng/mL placebo, = 0.04). There was a trend for a reduction in serum leptin concentrations after carnosine supplementation (-76 ± 165 ng/mL carnosine vs. 20 ± 28 ng/mL placebo, = 0.06). The changes in leptin and resistin concentrations were inversely related to the change in concentration for urinary carnosine ( = -0.72, = 0.0002; = -0.67, = 0.0009, respectively), carnosine-propanal ( = -0.56, = 0.005; = -0.63, = 0.001, respectively) and carnosine-propanol ( = -0.61, = 0.002; = -0.60, = 0.002, respectively). There were no differences between groups in change in adipsin concentrations. Our findings show carnosine supplementation may normalize some, but not all, of the serum adipokine concentrations involved in glucose metabolism, in overweight and obese individuals. Further clinical trials with larger samples are needed to confirm these results.

Address: Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria 3168, Australia. [email protected].; Institute of Experimental Endocrinology, Biomedical Research Centre, Slovak Academy of Sciences, 84236 Bratislava, Slovakia. [email protected].; Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Victoria 3800, Australia. [email protected].; Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria 3168, Australia. [email protected].; Institute of Experimental Endocrinology, Biomedical Research Centre, Slovak Academy of Sciences, 84236 Bratislava, Slovakia. [email protected].; Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria 3168, Australia. [email protected].; Department of Immunology and Pathology, Monash University, Melbourne, Victoria 3168, Australia. [email protected].; Department of Immunology and Pathology, Monash University, Melbourne, Victoria 3168, Australia. [email protected].; School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria 3001, Australia. [email protected].; Department of Pharmaceutical Sciences, Università degli Studi di Milano, 20133 Milan, Italy. [email protected].; Institute of Experimental Endocrinology, Biomedical Research Centre, Slovak Academy of Sciences, 84236 Bratislava, Slovakia. [email protected].; Institute of Pathological Physiology, Faculty of Medicine, Comenius University, 84215 Bratislava, Slovakia. [email protected].; Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria 3168, Australia. [email protected].

DOI: 10.3390/nu10091258

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MeSH Terms: Adult, Biomarkers, Carnosine, Dietary Supplements, Double-Blind Method, Down-Regulation, Female, Humans, Male, Middle Aged, Obesity, Pilot Projects, Resistin, Slovakia, Treatment Outcome