Translation Links Nutrient Availability with Inflammation.

Karine Boulay, Ivan Topisirovic, Frédérick A Mallette

Journal: Trends in biochemical sciences 2019;43(11):849-852

PMID: 30224182

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Abstract

Translation plays a crucial role in shaping the proteome during adaptation to various types of stress. A recent study by Gameiro and Struhl identified an inflammatory response which comprises coordination of transcriptional and translational programs, and which appears to be required for recovery from nutrient deprivation.

Address: Département de Biochimie et Médecine Moléculaire, CP 6128, Succursale Centre-Ville, Montréal, QC, H3C 3J7, Canada; Chromatin Structure and Cellular Senescence Research Unit, Maisonneuve-Rosemont Hospital Research Centre, Montréal, QC H1T 2M4, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC H3T 1E2, Canada. Electronic address: [email protected].; Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC H3T 1E2, Canada; Gerald Bronfman Department of Oncology, and Departments of Experimental Medicine, and Biochemistry McGill University, Montreal, QC H4A 3T2, Canada. Electronic address: [email protected].; Département de Biochimie et Médecine Moléculaire, CP 6128, Succursale Centre-Ville, Montréal, QC, H3C 3J7, Canada; Chromatin Structure and Cellular Senescence Research Unit, Maisonneuve-Rosemont Hospital Research Centre, Montréal, QC H1T 2M4, Canada; Département de Médecine, Université de Montréal, CP 6128, Succursale Centre-Ville, Montréal, QC H3C 3J7, Canada. Electronic address: [email protected].

DOI: 10.1016/j.tibs.2018.08.010

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MeSH Terms: Humans, Inflammation, Nutrients, Proteome