Biomarkers of Whole Grain Intake.

There is growing evidence that whole grain (WG) intake may prevent many chronic diseases. However, there are mixed results on this topic in human studies as a result of a lack of accurate tools to assess the intake of WGs and individual metabolic variation. To better understand the effects of WGs on health maintenance and the risk of chronic disease, there is an urgent need to identify the biomarkers for WG intake. The molecular signatures of WG intake remain undefined. This perspective gives an overview of the current knowledge, challenges, and future directions on the biomarkers of WG intake.