From fundamentals to applications of bioelectrocatalysis: bioelectrocatalytic reactions of FAD-dependent glucose dehydrogenase and bilirubin oxidase.

Seiya Tsujimura

Journal: Bioscience, biotechnology, and biochemistry 2019;83(1):39-48

PMID: 30274547

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Abstract

In this review, I present the main highlights of my works in the development of bioelectrocatalysis, which can be used in widespread applications, particularly for the design of biosensor and biofuel cells. In particular, I focus on research progress made in two key bioelectrocatalytic reactions: glucose oxidation by flavin adenine dinucleotide-dependent glucose dehydrogenase and oxygen reduction by bilirubin oxidase. I demonstrate the fundamental principles of bioelectrocatalysis and the requirements for enhancing the catalytic performance, including the choice of a mediator of redox reactions, immobilization, and electrode materials. These methods can allow for achieving control of the bioelectrocatalytic reaction, thereby overcoming obstacles toward their industrial applications.

Address: a Faculty of Pure and Applied Sciences , University of Tsukuba , Tsukuba , Japan.

DOI: 10.1080/09168451.2018.1527209

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MeSH Terms: Aspergillus, Biocatalysis, Bioelectric Energy Sources, Biological Oxygen Demand Analysis, Biosensing Techniques, Carbon, Electrochemical Techniques, Electrodes, Enzymes, Immobilized, Flavin-Adenine Dinucleotide, Glucose 1-Dehydrogenase, Hydrogels, Oxidation-Reduction, Oxidoreductases Acting on CH-CH Group Donors