The effects of fatty acids consumption on OPG/RANKL/RANK system in cardiovascular diseases: Current status and future perspectives for the impact of diet-gene interaction.

Omid Reza Tamtaji, Shokoofeh Borzabadi, Majid Ghayour-Mobarhan, Gordon Ferns, Zatollah Asemi

Journal: Journal of cellular biochemistry 2020;120(3):2774-2781

PMID: 30270544

Abstract

Cardiovascular disease (CVD) is an overall term that comprises a number of related pathologies, these include peripheral arterial disease, cerebrovascular disease, coronary heart disease (CHD), venous thromboembolism, and rheumatic and congenital heart diseases. Fatty acids in the diet have been reported to affect CVD. The OPG/RANKL/RANK system appears to have a role in CVD outcomes. However, there have been few studies on the impact of diet-gene interaction for effects of fatty acids consumption on the OPG/RANKL/RANK system in CVD. This review focuses on the effects of fatty acids on OPG/RANKL/RANK in CVD.

Address: Halal Research Center of IRI, FDA, Tehran, Iran.; Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.; Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK.; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

DOI: 10.1002/jcb.27672

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https://doi.org/10.1002/jcb.27672

MeSH Terms: Cardiovascular Diseases, Diet, Fatty Acids, Humans, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B