New Insights into the Pathogenesis and Treatment of Malnutrition.

Grace E Thaxton, Peter C Melby, Mark J Manary, Geoffrey A Preidis

Journal: Gastroenterology clinics of North America 2019;47(4):813-827

PMID: 30337034

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Abstract

The volume of research into the pathogenesis and treatment of malnutrition has increased markedly over the past ten years, providing mechanistic insights that can be leveraged into more effective treatment options. These discoveries have been driven by several landmark studies employing metabolomics, metagenomics, and new preclinical models. This review highlights some of the most important recent findings, focusing in particular on the emerging roles of prenatal and perinatal factors, protein deficiency, impaired gut barrier function, immune deficiency, and the intestinal microbiome.

Address: Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0435, USA.; Center for Tropical Diseases, Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0435, USA.; Department of Pediatrics, Washington University at St. Louis, One Brookings Drive, St Louis, MO 63110-1093, USA; School of Public Health and Family Medicine, College of Medicine, Private Bag 360. Chichiri, Blantyre 3, Malawi; United States Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, 1100 Bates Street, Houston, TX 77030, USA.; Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Feigin Tower, 1102 Bates Avenue, Suite 860, Houston, TX 77030, USA. Electronic address: [email protected].

DOI: 10.1016/j.gtc.2018.07.007

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MeSH Terms: Humans, Malnutrition