Chemistry of the fumiquinazolines and structurally related alkaloids.

Diana I S P Resende, Papichaya Boonpothong, Emília Sousa, Anake Kijjoa, Madalena M M Pinto

Journal: Natural product reports 2019;36(1):7-34

PMID: 30091435

Full Text on Royal Society of Chemistry View on PubMed

Abstract

Covering: this review covers the literature from 1992 to 2018To date, approximately 80 naturally-occurring secondary metabolites which are structurally-related to fumiquinazolines have been isolated, mainly from marine sources. These alkaloids can be classified into twelve different groups and exhibit different structure motifs depending on the amino acids from which they are derived. This review is focused on isolation, structure elucidation, biological activities, biosynthetic pathways, and synthetic studies of these natural products.

Address: Laboratory of Organic and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. [email protected] and Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, 4050-208, Matosinhos, Portugal.; Laboratory of Organic and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. [email protected].; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, 4050-208, Matosinhos, Portugal and ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

DOI: 10.1039/c8np00043c

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https://doi.org/10.1039/c8np00043c

MeSH Terms: Alkaloids, Quinazolines, Structure-Activity Relationship