Soluble resistance-related calcium-binding protein in cancers.

Xiao Yu, Jun Mao, Salma Mahmoud, He Huang, Qingqing Zhang, Jun Zhang

Journal: Clinica chimica acta; international journal of clinical chemistry 2019;486():369-373

PMID: 30144438

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Abstract

Soluble resistance-related calcium binding protein (Sorcin) is an oncoprotein expressed at high levels in human cancers and confers multidrug resistance (MDR) in several tumors. Sorcin participates in a number of neoplastic processing including metastasis and apoptosis. In this review, we summarize and discuss the relationship of Sorcin with tumors as well as its regulatory mechanisms. Sorcin is increasingly considered as a potential molecular target for therapeutic intervention.

Address: Department of Pathology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.; Teaching Laboratory of Morphology, Dalian Medical University, Dalian 116044, China.; Key Laboratory of Tumor Metastasis of Liaoning Province University, Dalian 116044, China.; Department of Pathology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China. Electronic address: [email protected].

DOI: 10.1016/j.cca.2018.08.034

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MeSH Terms: Antineoplastic Agents, Calcium-Binding Proteins, Drug Resistance, Multiple, Humans, Neoplasms, Solubility