Prevention of Prematurity: Advances and Opportunities.

Balaji Govindaswami, Priya Jegatheesan, Matthew Nudelman, Sudha Rani Narasimhan

Journal: Clinics in perinatology 2019;45(3):579-595

PMID: 30144857

Full Text on Elsevier Science View on PubMed

Abstract

Preterm birth (PTB) rate varies widely and has significant racial and ethnic disparities. Although causal mechanisms are ill understood, socioenvironment, phenotype, and genotype provide insight into pathways for preventing PTB. Data suggest varied response to current medical interventions is explicable Approved by underlying pharmacogenomics. Currently, prevention focuses on minimizing iatrogenic PTB and risk reduction especially in those with prior PTB using proven medical and public health strategies. In the future, preventive approaches will be based on better understanding of sociodemography, nutrition, lifestyles, and underlying individual genetic and epigenetic variation. Statistical approaches and "big-data" models are critical in future study.

Address: Division of Neonatology, Pediatrics, Santa Clara Valley Medical Center: Hospital and Clinics, 751 South Bascom Avenue, San Jose, CA 95128, USA. Electronic address: [email protected].; Division of Neonatology, Pediatrics, Santa Clara Valley Medical Center: Hospital and Clinics, 751 South Bascom Avenue, San Jose, CA 95128, USA.

DOI: 10.1016/j.clp.2018.05.013

Link outs

Free resources

Medical:

https://medlineplus.gov/quittingsmoking.html

Other Literature Sources:

https://scite.ai/reports/30144857

Subscription / membership required

Full Text Sources:

MeSH Terms: Anti-Infective Agents, Aspirin, Cerclage, Cervical, Cesarean Section, Female, Humans, Indomethacin, Labor, Induced, Magnesium Sulfate, Nifedipine, Pharmacogenetics, Platelet Aggregation Inhibitors, Preconception Care, Pregnancy, Premature Birth, Progesterone, Progestins, Reproductive Techniques, Assisted, Smoking Cessation, Tocolytic Agents