Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes: A systematic review and meta-analysis.

Dong-Wook Lee, Min-Seok Kim, Youn-Hee Lim, Nami Lee, Yun-Chul Hong

Journal: Environmental research 2019;167():558-566

PMID: 30145432

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

Di-(2-ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified. Therefore, a systematic review and meta-analysis focusing on the association between exposure to DEHP and neurodevelopmental outcomes is necessary, with particular attention to study design (longitudinal vs. cross-sectional).

METHODS

We performed a comprehensive literature search for associations between exposure to DEHP and neurodevelopmental outcomes. Among 106 published studies found in public databases, eight longitudinal studies and two cross-sectional studies were included in the meta-analysis.

RESULTS

We observed a statistically significant association between the concentrations of DEHP metabolites and the neurodevelopment outcomes of children among cross-sectional results, and found significant association between DEHP exposure measured in prenatal period and the psychomotor development outcomes measured later in childhood.

CONCLUSIONS

To our knowledge, this is the first meta-analysis of studies investigating the association between DEHP exposure and neurodevelopment in children. A need exists for more researches and a precautionary policy for potential health hazard of DEHP, the most commonly used phthalate, to promote healthier neurodevelopment in children.

Address: Department of Preventive Medicine, College of Medicine, Seoul National University, 103 Daehangno, Jongno-gu, Seoul 110-799, Republic of Korea.; Environmental Health Centre, College of Medicine, Seoul National University, Seoul, Republic of Korea; Institute of Environmental Medicine, Medical Research Centre, Seoul National University, Seoul, Republic of Korea.; Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea.; Department of Preventive Medicine, College of Medicine, Seoul National University, 103 Daehangno, Jongno-gu, Seoul 110-799, Republic of Korea; Environmental Health Centre, College of Medicine, Seoul National University, Seoul, Republic of Korea; Institute of Environmental Medicine, Medical Research Centre, Seoul National University, Seoul, Republic of Korea. Electronic address: [email protected].

DOI: 10.1016/j.envres.2018.08.023

Link outs

Free resources

Other Literature Sources:

https://scite.ai/reports/30145432

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0013...

MeSH Terms: Child, Child Development, Cross-Sectional Studies, Diethylhexyl Phthalate, Female, Humans, Longitudinal Studies, Pregnancy, Prenatal Exposure Delayed Effects, Psychomotor Disorders