Terpenoids from the stems of Celastrus hindsii and their anti-RSV activities.

Ding Luo, Si Xiong, Qing-Guo Li, Lin Jiang, Qian-Wen Niu, Li-Jun He, Yao-Lan Li, Yu-Bo Zhang, Guo-Cai Wang

Journal: Fitoterapia 2018;130():118-124

PMID: 30165177

Full Text on Elsevier Science View on PubMed

Abstract

Two new oleanane-type triterpenoids (1-2), a new ursane-type triterpenoid (3), and a new podocarpane-type diterpenoid (4), together with 20 known compounds (5-24) were isolated from the stems of Celastrus hindsii Benth. Their structures were identified on the basis of the spectral data (HRESIMS, IR, UV, 1D, and 2D NMR) and the absolute configurations were determined by comparison of experimental and calculated ECD data. The structures of 1 and 4 were further confirmed by single crystal X-ray diffraction analysis. In addition, all compounds were evaluated for their in vitro antiviral activities against respiratory syncytium virus (RSV) using cytopathic effect (CPE) reduction assay. Compounds 7, 10, 11, 19 and 24 exhibited obvious anti-RSV activity with IC values from 1.55 to 6.25 μM.

Address: Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.; Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, PR China. Electronic address: [email protected].; Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, PR China. Electronic address: [email protected].

DOI: 10.1016/j.fitote.2018.08.018

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https://assays.cancer.gov/CPTAC-1486

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https://antibodies.cancer.gov/detail/CPTC-CPE-1

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MeSH Terms: Antiviral Agents, Celastrus, China, Molecular Structure, Oleanolic Acid, Phytochemicals, Plant Stems, Respiratory Syncytial Virus, Human