Euphosantianane A⁻D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant .

Mohamed-Elamir F Hegazy, Ahmed R Hamed, Mahmoud A A Ibrahim, Zienab Talat, Eman H Reda, Nahla S Abdel-Azim, Faiza M Hammouda, Seikou Nakamura, Hisashi Matsuda, Eman G Haggag, Paul W Paré, Thomas Efferth

Journal: Molecules (Basel, Switzerland) 2018;23(9):2221

PMID: 30200407

Free Full Text on MDPI View on PubMed

Abstract

species are rich in diterpenes. A solvent extraction of , a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (⁻) as well as previously reported metabolites (⁻) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound exhibited robust anti-proliferative activity against A549 cells (IC = 3.3 µM). Absolute configurations for versus were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.

Address: Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt. [email protected].; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. [email protected].; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt. [email protected].; Biology Unit, Central Laboratory for Pharmaceutical and Drug Industries Research Division, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt. [email protected].; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt. [email protected].; Phytochemistry Lab., National Organization for Drug Control and Research, Giza 12622, Egypt. [email protected].; Phytochemistry Lab., National Organization for Drug Control and Research, Giza 12622, Egypt. [email protected].; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt. [email protected].; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt. [email protected].; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. [email protected].; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. [email protected].; Department of Pharmacognosy, Helwan University, Cairo 12622, Egypt. [email protected].; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA. [email protected].; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. [email protected].

DOI: 10.3390/molecules23092221

Link outs

Free resources

Full Text Sources:

Other Literature Sources:

https://scite.ai/reports/30200407

MeSH Terms: A549 Cells, Caco-2 Cells, Carbon-13 Magnetic Resonance Spectroscopy, Cell Proliferation, Circular Dichroism, Diterpenes, Euphorbia, Humans, Inhibitory Concentration 50, Proton Magnetic Resonance Spectroscopy