Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers.

Andrea Polo, Silvia Marchese, Giuseppina De Petro, Maurizio Montella, Gennaro Ciliberto, Alfredo Budillon, Susan Costantini

Journal: Scientific reports 2019;8(1):10395

PMID: 29991691

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Abstract

Arsenic and arsenic-derivative compounds, named as arsenicals, represent a worldwide problem for their effect on the human health and, in particular, for their capability to increase the risk of developing cancer such as kidney, bladder and prostate cancer. The main source of arsenical exposure is drinking water. Nowadays, it is well known that the chronic exposure to arsenicals leads to a series of epigenetic alterations that have a role in arsenic-induced effects on human health including cancer. Based on these observations, the aim of our study was to select by network analysis the genes/proteins/miRNAs implicated in kidney, bladder and prostate cancer development upon arsenical exposure. From this analysis we identified: (i) the nodes linking the three molecular networks specific for kidney, bladder and prostate cancer; (ii) the relative HUB nodes (RXRA, MAP3K7, NR3C1, PABPC1, NDRG1, RELA and CTNNB1) that link the three cancer networks; (iii) the miRNAs able to target these HUB nodes. In conclusion, we highlighted a panel of potential molecules related to the molecular mechanisms of arsenical-induced cancerogenesis and suggest their utility as biomarkers or therapeutic targets.

Address: Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy.; Dipartimento di Medicina Molecolare e Traslazionale, Università di Brescia, Brescia, Italy.; Epidemiology Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy.; Scientific Directorate, IRCCS Istituto Nazionale Tumori "Regina Elena", Roma, Italy.; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy. [email protected].; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy. [email protected].

DOI: 10.1038/s41598-018-28739-6

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Medical:

https://medlineplus.gov/prostatecancer.html

Other Literature Sources:

https://scite.ai/reports/29991691

Miscellaneous:

https://assays.cancer.gov/CPTAC-1745

MeSH Terms: Arsenicals, Cell Cycle Proteins, Disease-Free Survival, Drinking Water, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Humans, Intracellular Signaling Peptides and Proteins, Kidney Neoplasms, MAP Kinase Kinase Kinases, Male, MicroRNAs, Poly(A)-Binding Proteins, Prostatic Neoplasms, Receptors, Glucocorticoid, Retinoid X Receptor alpha, Transcription Factor RelA, Urinary Bladder Neoplasms, beta Catenin