Acute and chronic effects of exercise on the kynurenine pathway in humans - A brief review and future perspectives.

Alan J Metcalfe, Christina Koliamitra, Florian Javelle, Wilhelm Bloch, Philipp Zimmer

Journal: Physiology & behavior 2019;194():583-587

PMID: 30031753

Full Text on Elsevier Science View on PubMed

Abstract

Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.

Address: German Sport University Cologne, Department of Molecular and Cellular Medicine, Cologne, Germany; Northumbria University, Health and Life Sciences, Newcastle Upon Tyne, United Kingdom.; German Sport University Cologne, Department of Molecular and Cellular Medicine, Cologne, Germany.; German Sport University Cologne, Department of Molecular and Cellular Medicine, Cologne, Germany; German Cancer Research Centre, Division of Physical Activity, Prevention and Cancer, Heidelberg, Germany. Electronic address: [email protected].

DOI: 10.1016/j.physbeh.2018.07.015

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MeSH Terms: Exercise, Humans, Kynurenine, Signal Transduction, Tryptophan