Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study.

Sumanto Haldar, Sze Han Lee, Jun Jie Tan, Siok Ching Chia, Christiani Jeyakumar Henry, Eric Chun Yong Chan

Journal: Nutrients 2018;10(7):934

PMID: 30037045

Abstract

Spices that are rich in polyphenols are metabolized to a convergent group of phenolic/aromatic acids. We conducted a dose-exposure nutrikinetic study to investigate associations between mixed spices intake and plasma concentrations of selected, unconjugated phenolic/aromatic acids. In a randomized crossover study, 17 Chinese males consumed a curry meal containing 0 g, 6 g, and 12 g of mixed spices. Postprandial blood was drawn up to 7 h at regular intervals and plasma phenolic/aromatic acids were quantified via liquid chromatography tandem mass spectrometry (LC-MS/MS). Cinnamic acid (CNA, < 0.0001) and phenylacetic acid (PAA, < 0.0005) concentrations were significantly increased with mixed spices consumption, although none of the other measured phenolic/aromatic acids differ significantly between treatments. CNA displayed a high dose-exposure association (R² > 0.8, < 0.0001). The adjusted mean area under the plasma concentration-time curve until 7 h (AUC) for CNA during the 3 increasing doses were 8.4 ± 3.4, 376.1 ± 104.7 and 875.7 ± 291.9 nM.h respectively. Plasma CNA concentration may be used as a biomarker of spice intake.

Address: Clinical Nutrition Research Centre, Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, Singapore 117599, Singapore. [email protected].; Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore. [email protected].; Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore. [email protected].; Clinical Nutrition Research Centre, Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, Singapore 117599, Singapore. [email protected].; Clinical Nutrition Research Centre, Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, Singapore 117599, Singapore. [email protected].; Department of Biochemistry, National University of Singapore, Singapore 117596, Singapore. [email protected].; Clinical Nutrition Research Centre, Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, Singapore 117599, Singapore. [email protected].; Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore. [email protected].

DOI: 10.3390/nu10070934

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MeSH Terms: Adult, Area Under Curve, Biomarkers, Capsicum, Chromatography, Liquid, Cinnamates, Cinnamomum zeylanicum, Coriandrum, Cross-Over Studies, Cuminum, Curcuma, Diet, Dose-Response Relationship, Drug, Eating, Humans, Male, Phenylacetates, Plant Extracts, Plasma, Polyphenols, Postprandial Period, Spices, Young Adult