New Ultrasound Techniques Challenge the Diagnosis of Sinusoidal Obstruction Syndrome.

Christoph F Dietrich, Corinna Trenker, Teresa Fontanilla, Christian Görg, Andreas Hausmann, Stefan Klein, Nathalie Lassau, Rosa Miquel, Dagmar Schreiber-Dietrich, Yi Dong

Journal: Ultrasound in medicine & biology 2019;44(11):2171-2182

PMID: 30076031

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Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation. Clinically, SOS/VOD is characterized by hepatomegaly, right upper quadrant pain, jaundice and ascites, most often occurring within the first 3 wk after hematopoietic cell transplantation. Early therapeutic intervention is pivotal for survival in SOS/VOD. Thus, a rapid and reliable diagnosis has to be made. Diagnosis of SOS/VOD is based on clinical criteria, such as the Seattle, Baltimore or recently issued European Society for Blood and Marrow Transplantation criteria, to which hemodynamic and/or ultrasound evidence of SOS were added for the first time. However, to rule out major differential diagnoses and to verify the diagnosis, a reliable imaging method is needed. Ultrasound techniques have been proposed in SOS/VOD. Nevertheless, the sensitivity and specificity of transabdominal ultrasound and Doppler techniques need to be improved. Innovative ultrasound methods such as a combination of Doppler ultrasound with shear wave elastography and contrast-enhanced ultrasound techniques should be evaluated for diagnosis and follow-up of SOS/VOD. The goals of this review are to discuss currently available ultrasound techniques and to identify areas for future studies in SOS/VOD.

Address: Department of Internal Medicine 2, Caritas Krankenhaus, Bad Mergentheim, Germany; Ultrasound Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address: [email protected].; Department of Haematology, Oncology and Immunology, University Hospital Giessen and Marburg, Philipps University Marburg, Marburg, Germany.; Radiology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.; Interdisciplinary Center of Ultrasound, University Hospital Giessen and Marburg, Philipps University Marburg, Marburg, Germany.; MLL Münchner Leukämielabor GmbH, München, Germany.; Department of Hematology and Oncology, University Clinic Mannheim, Mannheim, Germany.; Gustave Roussy Imaging Department, CNRS Université Paris-Sud, Paris, France.; Liver Histopathology, Institute of Liver Studies, King's College Hospital, London, United Kingdom.; Pediatric Department, Caritas Krankenhaus, Bad Mergentheim, Germany.; Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.

DOI: 10.1016/j.ultrasmedbio.2018.06.002

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MeSH Terms: Hepatic Veno-Occlusive Disease, Humans, Liver, Ultrasonography