Epithelial mesenchymal transition Transcription Factor (TF): The structure, function and microRNA feedback loop.

Neda Alidadiani, Shahrooz Ghaderi, Nafi Dilaver, Saina Bakhshamin, Mansour Bayat

Journal: Gene 2018;674():115-120

PMID: 29936265

Full Text on Elsevier Science View on PubMed

Abstract

Epithelial to mesenchymal transition (EMT) is a phenomenon in which epithelial cells lose their cell to cell adhesion and detach from the base of the membrane. EMT is a fundamental process which occurs during tumor progression and metastasis. Cancer genomics is a complex network which involves a variety of factors such as transcription factors (TFs), coding genes and microRNAs (miRs). Both TFs and miRs are trans-regulatory elements that crosstalk. Due to a wide range of targets, TF-miR interaction provides a feedback or feedforward loop and cross-gene regulation consequently. In this review, we focused on the structure and function of two TF families involved in EMT, zinc finger and β helix loop helix and p53. Subsequently we analyzed recent findings on TF-miR interaction in EMT.

Address: Department of system physiology, Rhur University Bochum, Bochum, Germany.; Department of system physiology, Rhur University Bochum, Bochum, Germany. Electronic address: [email protected].; Swansea University, College of Medicine, Swansea, United Kingdom.; Young Researchers and Elite Club, Islamic Azad University, Tehran, Iran.; Department of Mycology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Electronic address: [email protected].

DOI: 10.1016/j.gene.2018.06.049