Sensitization of prostate cancer to radiation therapy: Molecules and pathways to target.

Mu Yao, Linda Rogers, Natalka Suchowerska, Daniel Choe, Mahmoud A Al-Dabbas, Ramit S Narula, J Guy Lyons, Paul Sved, Zhong Li, Qihan Dong

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2018;128(2):283-300

PMID: 29929859

Full Text on Elsevier Science View on PubMed

Abstract

Radiation therapy is used to treat cancer by radiation-induced DNA damage. Despite the best efforts to eliminate cancer, some cancer cells survive irradiation, resulting in cancer progression or recurrence. Alteration in DNA damage repair pathways is common in cancers, resulting in modulation of their response to radiation. This article focuses on the recent findings about molecules and pathways that potentially can be targeted to sensitize prostate cancer cells to ionizing radiation, thereby achieving an improved therapeutic outcome.

Address: Central Clinical School and Charles Perkins Centre, Australia; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.; Department of Radiation Oncology, Chris O'Brien Lifehouse, Sydney, Australia; School of Physics, University of Sydney, Australia.; School of Science and Health, Western Sydney University, Australia.; School of Science and Health, Western Sydney University, Australia; School of Medicine, Western Sydney University, Australia.; Central Clinical School and Charles Perkins Centre, Australia; Cancer Services, Royal Prince Alfred Hospital, Sydney, Australia; Immune Imaging Program, Centenary Institute, Sydney, Australia.; Department of Urology, Bankstown-Lidcombe Hospital, Sydney, Australia.; Dongzhimen Hospital, Beijing University of Chinese Medicine, China. Electronic address: [email protected].; Central Clinical School and Charles Perkins Centre, Australia; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia; School of Science and Health, Western Sydney University, Australia. Electronic address: [email protected].

DOI: 10.1016/j.radonc.2018.05.021