Cutaneous and Mucosal Manifestations Associated with Celiac Disease.

Luis Rodrigo, Valia Beteta-Gorriti, Nuria Alvarez, Celia Gómez de Castro, Alvaro de Dios, Laura Palacios, Jorge Santos-Juanes

Journal: Nutrients 2019;10(7):800

PMID: 29933630

Free Full Text on MDPI View on PubMed

Abstract

Celiac disease (CD) is an immune-mediated, gluten-induced enteropathy that affects predisposed individuals of all ages. Many patients with CD do not report gastrointestinal symptoms making it difficult to reach an early diagnosis. On the other hand, CD is related to a wide spectrum of extra-intestinal manifestations, with dermatitis herpetiformis (DH) being the best characterized. These associated conditions may be the clue to reaching the diagnosis of CD. Over the last few years, there have been multiple reports of the association between CD and several cutaneous manifestations that may improve with a gluten-free diet (GFD). The presence of some of these skin diseases, even in the absence of gastrointestinal symptoms, should give rise to an appropriate screening method for CD. The aim of this paper is to describe the different cutaneous manifestations that have been associated with CD and the possible mechanisms involved.

Address: Gastroenterology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Asturias, Spain. [email protected].; Dermatology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Asturias, Spain. [email protected].; Gastroenterology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Asturias, Spain. [email protected].; Dermatology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Asturias, Spain. [email protected].; Dermatology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Asturias, Spain. [email protected].; Dermatology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Asturias, Spain. [email protected].; Dermatology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Asturias, Spain. [email protected].; Facultad de Medicina, Universidad de Oviedo, 33003 Oviedo, Asturias, Spain. [email protected].

DOI: 10.3390/nu10070800

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/skinconditions.html

Other Literature Sources:

https://scite.ai/reports/29933630

MeSH Terms: Alopecia Areata, Celiac Disease, Dermatitis Herpetiformis, Dermatitis, Atopic, Diet, Gluten-Free, Gastrointestinal Diseases, Glutens, Humans, Mucous Membrane, Psoriasis, Rosacea, Skin, Skin Diseases, Stomatitis, Aphthous, Urticaria, Vasculitis, Leukocytoclastic, Cutaneous