Chemical Structures and Biological Activities of Limonoids from the Genus (Meliaceae).

Yun-Peng Sun, Wen-Fang Jin, Yong-Yue Wang, Gang Wang, Susan L Morris-Natschke, Jin-Song Liu, Guo-Kai Wang, Kuo-Hsiung Lee

Journal: Molecules (Basel, Switzerland) 2018;23(7):1588

PMID: 29966275

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Abstract

is a genus in the plant family Meliaceae. This genus contains seven to eight known species, found in the tropical and subtropical regions of the Americas and West Africa. Thus far, more than 160 limonoids have been isolated from four species of the genus . Limonoids are rich in structure type and biological activity, and these compounds are the main active components in the species. This paper will give a comprehensive overview of the recent phytochemical and pharmacological research on the terpenes from plants and encourage further drug discovery research.

Address: School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. [email protected].; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. [email protected].; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. [email protected].; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. [email protected].; Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, China. [email protected].; Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA. [email protected].; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. [email protected].; Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, China. [email protected].; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. [email protected].; Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, China. [email protected].; Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA. [email protected].; Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA. [email protected].; Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan. [email protected].

DOI: 10.3390/molecules23071588

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MeSH Terms: Anti-Infective Agents, Anti-Inflammatory Agents, Hypoglycemic Agents, Limonins, Meliaceae, Molecular Structure, Structure-Activity Relationship