Union of light ion therapy centers in Europe (ULICE EC FP7) - Objectives and achievements of joint research activities.

Michael Krämer, Dietmar Georg, Roberto Orecchia, Jürgen Debus, Manjit Dosanjh, Thomas Schreiner, Marco Pullia, Ulrike Mock, Ramona Mayer, Richard Pötter, Bleddyn Jones, Steve Harris, Piero Fossati, Wolfgang Enghardt, Jim Davies, Christoph Bert, Michael Baumann, Jaques Balosso

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2018;128(1):83-100

PMID: 30001932

Full Text on Elsevier Science View on PubMed

Abstract

Under the umbrella of the European Network for Light Ion Therapy (ENLIGHT), the project on Union of Light Ion Centers in Europe (ULICE), which was funded by the European Commission (EC/FP7), was carried out from 2009 to 2014. Besides the two pillars on Transnational Access (TNA) and Networking Activities (NA), six work packages formed the pillar on Joint Research Activities (JRA). The current manuscript focuses on the objectives and results achieved within these research work packages: "Clinical Research Infrastructure", "Biologically Based Expert System for Individualized Patient Allocation", "Ion Therapy for Intra-Fractional Moving Targets", "Adaptive Treatment Planning for Ion Radiotherapy", "Carbon Ion Gantry", "Common Database and Grid Infrastructures for Improving Access to Research Infrastructures". The objectives and main achievements are summarized. References to either publications or open access deliverables from the five year project work are given. Overall, carbon ion radiotherapy is still not as mature as photon or proton radiotherapy. Achieved results and open questions are reflected and discussed in the context of the current status of carbon ion therapy and particle and photon beam therapy. Most research topics covered in the ULICE JRA pillar are topical. Future research activities can build upon these ULICE results. Together with the continuous increase in the number of particle therapy centers in the last years ULICE results and proposals may contribute to the further growth of the overall particle therapy field as foreseen with ENLIGHT and new joint initiatives such as the European Particle Therapy Network (EPTN) within the overall radiotherapy community.

Address: Department of Radiation Oncology, Medical University of Vienna/AKH Wien, Austria.; Departement of Radiation Oncology and Medical Physics, University Grenoble Alpes (UGA) and Centre Hospitalier Universitaire Grenoble Alpes (CHUGA), France.; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; Department of Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; Institute of Radiation Oncology, Helmholtz-Zentrum Dresden-Rossendorf, Germany; German Cancer Consortium (DKTK), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.; Department of Computer Science, University of Oxford, UK.; EBG MedAustron GmbH, Wiener Neustadt, Austria.; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, UK.; Gray Laboratory, CRUK/MRC Oxford Oncology Institute, The University of Oxford, UK.; Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.; Centro Nazionale di Adroterapia Oncologica (CNAO), Pavia, Italy.; CERN, Geneva, Switzerland.; Department of Radiation Oncology, University Hospital of Heidelberg, Germany; Heidelberg Ion Therapy Center (HIT), Germany.; Centro Nazionale di Adroterapia Oncologica (CNAO), Pavia, Italy; Division of Radiation Oncology, European Institute of Oncology, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Italy.; Department of Radiation Oncology, Medical University of Vienna/AKH Wien, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Austria. Electronic address: [email protected].

DOI: 10.1016/j.radonc.2018.04.027

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MeSH Terms: Biomedical Research, Databases, Factual, Europe, Heavy Ion Radiotherapy, Humans, Ions, Neoplasms, Photons, Proton Therapy, Radiotherapy, Research