A single blind comparison of amisulpride, fluoxetine and clomipramine in the treatment of restricting anorectics.

G M Ruggiero, V Laini, M C Mauri, V M Ferrari, A Clemente, F Lugo, M Mantero, G Redaelli, D Zappulli, F Cavagnini

Journal: Progress in neuro-psychopharmacology & biological psychiatry 2001;25(5):1049-59

PMID: 11444677

Full Text on Elsevier Science View on PubMed

Abstract

1. The study evaluated the efficacy of amisulpride, fluoxetine and clomipramine at the beginning of the re-feeding phase of the treatment of restricting anorexia nervosa according to DSM-IV criteria. 2. 13 patients, mean weight 37.61 kg +/- 9.80 SD, were treated with clomipramine at a mean dosage of 57.69 mg +/- 25.79 SD; 10 patients, mean weight 40.90 kg +/- 6.98 SD, were treated with fluoxetine at a mean dosage of 28.00 mg +/- 10.32 SD; 12 patients, mean weight 38.41 kg +/- 8.33 SD, were treated with amisulpride at a mean dosage of 50.00 mg +/- 0.00 SD. 3. Clinical evaluation was carried out under single-blind condition at basal time and after three months by a structured clinical interview, the Eating Disorder Interview based on Long Interval Follow-up Evaluation (LIFE II BEI). 4. Patients treated with amisulpride showed a more significant increase (p=0.016) of mean weight. Concerning weight phobia, body image disturbance and amenorrhoea, no significant difference resulted.

Address: Department of Clinical Psychiatry, University of Milan, Italy.

DOI: 10.1016/s0278-5846(01)00174-9

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MeSH Terms: Adult, Amenorrhea, Amisulpride, Anorexia Nervosa, Antidepressive Agents, Second-Generation, Antidepressive Agents, Tricyclic, Antipsychotic Agents, Body Image, Clomipramine, Diet Therapy, Drug Therapy, Combination, Female, Fluoxetine, Humans, Male, Single-Blind Method, Sulpiride, Treatment Outcome, Weight Gain