Involvement of miRNAs and Pseudogenes in Cancer.

Lütfi Tutar, Aykut Özgür, Yusuf Tutar

Journal: Methods in molecular biology (Clifton, N.J.) 2018;1699():45-66

PMID: 29086367

Abstract

Our understanding of cancer pathways has been changed by the determination of noncoding transcripts in the human genome in recent years. miRNAs and pseudogenes are key players of the noncoding transcripts from the genome, and alteration of their expression levels provides clues for significant biomarkers in pathogenesis of diseases. Especially, miRNAs and pseudogenes have both oncogenic and tumor-suppressive roles in each step of cancer tumorigenesis. In this current study, association between oncogenes and miRNAs-pseudogenes was reviewed and determined in human cancer by the CellMiner web-tool.

Address: Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Ahi Evran University, Kırşehir, Turkey.; Division of Biochemistry, Department of Basic Sciences, Faculty of Pharmacy, Cumhuriyet University, 58140, Sivas, Turkey.; Division of Biochemistry, Department of Basic Sciences, Faculty of Pharmacy, Cumhuriyet University, 58140, Sivas, Turkey. [email protected].; Department of Nutrition and Dietetics, Health Sciences Faculty, University of Health Sciences, Üsküdar, Istanbul, 34668, Turkey. [email protected].

DOI: 10.1007/978-1-4939-7435-1_3

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MeSH Terms: Biomarkers, Tumor, Databases, Nucleic Acid, Gene Expression Regulation, Neoplastic, Humans, MicroRNAs, Neoplasms, Oncogenes, Pseudogenes