Simultaneous recording of cervical and ocular vestibular-evoked myogenic potentials.

Sun-Young Oh, Hyun-June Shin, Rainer Boegle, Matthias Ertl, Peter Zu Eulenburg, Ji-Soo Kim, Marianne Dieterich

Journal: Neurology 2019;90(3):e230-e238

PMID: 29263227

Abstract

OBJECTIVE

To increase clinical application of vestibular-evoked myogenic potentials (VEMPs) by reducing the testing time by evaluating whether a simultaneous recording of ocular and cervical VEMPs can be achieved without a loss in diagnostic sensitivity and specificity.

METHODS

Simultaneous recording of ocular and cervical VEMPs on each side during monaural stimulation, bilateral simultaneous recording of ocular VEMPs and cervical VEMPs during binaural stimulation, and conventional sequential recording of ocular and cervical VEMPs on each side using air-conducted sound (500 Hz, 5-millisecond tone burst) were compared in 40 healthy participants (HPs) and 20 patients with acute vestibular neuritis.

RESULTS

Either simultaneous recording during monaural and binaural stimulation effectively reduced the recording time by ≈55% of that for conventional sequential recordings in both the HP and patient groups. The simultaneous recording with monaural stimulation resulted in latencies and thresholds of both VEMPs and the amplitude of cervical VEMPs similar to those found during the conventional recordings but larger ocular VEMP amplitudes (156%) in both groups. In contrast, compared to the conventional recording, simultaneous recording of each VEMP during binaural stimulation showed reduced amplitudes (31%) and increased thresholds for cervical VEMPs in both groups.

CONCLUSIONS

The results of simultaneous recording of cervical and ocular VEMPs during monaural stimulation were comparable to those obtained from the conventional recording while reducing the time to record both VEMPs on each side.

CLINICALTRIALSGOV IDENTIFIER

NCT03049683.

Address: From the Department of Neurology (S.-Y.O., H.-J.S.), Chonbuk National University School of Medicine; Research Institute of Clinical Medicine (S.-Y.O., H.-J.S.), Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea; Department of Neurology (S.-Y.O., M.E., P.z.E., M.D.) and German Center for Vertigo and Balance Disorders (R.B., M.D.), University Hospital, and Graduate School of Systemic Neuroscience (R.B., M.E., P.z.E., M.D.), Ludwig-Maximilians-University; Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany; and Department of Neurology (J.-S.K.), Seoul National University School of Medicine, Korea. [email protected].; From the Department of Neurology (S.-Y.O., H.-J.S.), Chonbuk National University School of Medicine; Research Institute of Clinical Medicine (S.-Y.O., H.-J.S.), Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea; Department of Neurology (S.-Y.O., M.E., P.z.E., M.D.) and German Center for Vertigo and Balance Disorders (R.B., M.D.), University Hospital, and Graduate School of Systemic Neuroscience (R.B., M.E., P.z.E., M.D.), Ludwig-Maximilians-University; Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany; and Department of Neurology (J.-S.K.), Seoul National University School of Medicine, Korea.

DOI: 10.1212/WNL.0000000000004835

Link outs

Free resources

Medical:

https://clinicaltrials.gov/search?term=AREA%5BRefe...

Other Literature Sources:

https://scite.ai/reports/29263227

Miscellaneous:

https://assays.cancer.gov/CPTAC-671

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-DLC1-1

Subscription / membership required

Full Text Sources:

MeSH Terms: Acoustic Stimulation, Adult, Aged, Auditory Perception, Cross-Over Studies, Electromyography, Female, Humans, Male, Middle Aged, Vestibular Evoked Myogenic Potentials, Vestibular Function Tests, Vestibular Neuronitis, Young Adult