Complement factor H family proteins in their non-canonical role as modulators of cellular functions.

Mihály Józsi, Andrea E Schneider, Éva Kárpáti, Noémi Sándor

Journal: Seminars in cell & developmental biology 2019;85():122-131

PMID: 29305301

Abstract

Complement factor H is a major regulator of the alternative pathway of the complement system. The factor H-related proteins are less characterized, but recent data indicate that they rather promote complement activation. These proteins have some common ligands with factor H and have both overlapping and distinct functions depending on domain composition and the degree of conservation of amino acid sequence. Factor H and some of the factor H-related proteins also appear in a non-canonical function that is beyond their role in the modulation of complement activation. This review covers our current understanding on this emerging role of factor H family proteins in modulating the activation and function of various cells by binding to receptors or receptor ligands.

Address: Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary; MTA-ELTE Immunology Research Group, Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary. Electronic address: [email protected].; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.

DOI: 10.1016/j.semcdb.2017.12.018