Ki-67: more than a proliferation marker.

Xiaoming Sun, Paul D Kaufman

Journal: Chromosoma 2019;127(2):175-186

PMID: 29322240

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Abstract

Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and its cellular distribution dramatically changes during cell cycle progression. These localizations correlate with distinct functions. For example, during interphase, Ki-67 is required for normal cellular distribution of heterochromatin antigens and for the nucleolar association of heterochromatin. During mitosis, Ki-67 is essential for formation of the perichromosomal layer (PCL), a ribonucleoprotein sheath coating the condensed chromosomes. In this structure, Ki-67 acts to prevent aggregation of mitotic chromosomes. Here, we present an overview of functional roles of Ki-67 across the cell cycle and also describe recent experiments that clarify its role in regulating cell cycle progression in human cells.

Address: Department of Molecular, Cell and Cancer Biology, University Massachusetts Medical School, 364 Plantation St. #506, Worcester, MA, 01605, USA.; Department of Molecular, Cell and Cancer Biology, University Massachusetts Medical School, 364 Plantation St. #506, Worcester, MA, 01605, USA. [email protected].

DOI: 10.1007/s00412-018-0659-8

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https://dx.doi.org/10.1007/s00412-018-0659-8

MeSH Terms: Amino Acid Sequence, Cell Line, Tumor, Cell Nucleolus, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p21, Gene Expression Regulation, Heterochromatin, Humans, Interphase, Ki-67 Antigen, Mitosis, Protein Domains, Protein Isoforms, Retinoblastoma Protein, Ribonucleoproteins, Tumor Suppressor Protein p53