Genome Editing: Targeting Susceptibility Genes for Plant Disease Resistance.

Syed Shan-E-Ali Zaidi, M Shahid Mukhtar, Shahid Mansoor

Journal: Trends in biotechnology 2019;36(9):898-906

PMID: 29752192

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Abstract

Plant pathogens pose a major threat to crop productivity. Typically, phytopathogens exploit plants' susceptibility (S) genes to facilitate their proliferation. Disrupting these S genes may interfere with the compatibility between the host and the pathogens and consequently provide broad-spectrum and durable disease resistance. In the past, genetic manipulation of such S genes has been shown to confer disease resistance in various economically important crops. Recent studies have accomplished this task in a transgene-free system using new genome editing tools, including clustered regularly interspaced palindromic repeats (CRISPR). In this Opinion article, we focus on the use of genome editing to target S genes for the development of transgene-free and durable disease-resistant crop varieties.

Address: Gembloux Agro-Bio Tech, University of Liège, Gembloux 5030, Belgium; National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan. Electronic address: http://twitter.com/@SyedShanZaidi.; Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: http://twitter.com/@SMukhtarlab.; National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan. Electronic address: [email protected].

DOI: 10.1016/j.tibtech.2018.04.005

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MeSH Terms: Agrobacterium tumefaciens, Bacterial Infections, CRISPR-Associated Protein 9, CRISPR-Cas Systems, Crops, Agricultural, Disease Resistance, Disease Susceptibility, Gene Editing, Gene Transfer Techniques, Genome, Plant, Mycoses, Oryza, Plant Diseases, RNA, Guide, CRISPR-Cas Systems, Triticum, Virus Diseases, Zea mays