Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia, in patients with newly diagnosed colorectal cancer: a randomized controlled clinical trial.

A González-Sarrías, M A Núñez-Sánchez, M A Ávila-Gálvez, T Monedero-Saiz, F J Rodríguez-Gil, Francisco Martínez-Díaz, M V Selma, J C Espín

Journal: Food & function 2018;9(5):2617-2622

PMID: 29770393

Full Text on Royal Society of Chemistry View on PubMed

Abstract

Gut microbiota dysbiosis alters the intestinal barrier function, increases plasma lipopolysaccharide (LPS) levels, which promotes endotoxemia, and contributes to the onset and development of colorectal cancer (CRC). We report here for the first time the reduction of plasma LPS-binding protein (LBP) levels, a marker of endotoxemia, after pomegranate consumption in newly diagnosed CRC patients.

Address: Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Campus de Espinardo, Murcia, Spain. [email protected].

DOI: 10.1039/c8fo00264a

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https://doi.org/10.1039/c8fo00264a

MeSH Terms: Acute-Phase Proteins, Aged, Aged, 80 and over, Biomarkers, Carrier Proteins, Colorectal Neoplasms, Endotoxemia, Environmental Biomarkers, Female, Fruit, Humans, Lythraceae, Male, Membrane Glycoproteins, Middle Aged