Environmental Signals Influencing Myeloid Cell Metabolism and Function in Diabetes.

Jacqueline M Ratter, Cees J Tack, Mihai G Netea, Rinke Stienstra

Journal: Trends in endocrinology and metabolism: TEM 2019;29(7):468-480

PMID: 29789206

Full Text on Elsevier Science View on PubMed

Abstract

The environment induces metabolic reprogramming of immune cells via specific signaling pathways. Recent studies have revealed that changes in cell metabolism affect key immune cell functions including cytokine production and migration. In diabetes, these functions are either insufficiently or excessively activated, translating into diabetes-associated complications, including increased susceptibility to infection and accelerated cardiovascular disease. Diabetes alters the abundance of environmental signals, including glucose, insulin, and lipids. Subsequently, changes in environmental signals drive metabolic reprogramming, impair immune cell function, and ultimately contribute to diabetes-associated complications. We review here recent studies on changes in innate immune cell metabolism, especially in myeloid cells, that are driven by environmental signals relevant to diabetes, and discuss therapeutic perspectives of targeting metabolism of immune cells in diabetes.

Address: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department for Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands. Electronic address: [email protected].

DOI: 10.1016/j.tem.2018.04.008

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MeSH Terms: Diabetes Mellitus, Humans, Inflammation, Macrophages, Myeloid Cells, Signal Transduction