Motile organelles: the importance of specific tubulin isoforms.

S K Dutcher

Journal: Current biology : CB 2001;11(11):R419-22

PMID: 11516662

Free Full Text on Elsevier Science View on PubMed

Abstract

The requirements for building flagellar axonemes and centrioles are beginning to be uncovered. The carboxyl terminus of a specific beta tubulin isoform plays an important role in forming the '9 + 2' structure of the axoneme; delta tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.

Address: Department of Genetics, Washington University School of Medicine, 660 s. Euclid, St. Louis, Missouri 63110, USA. [email protected]

DOI: 10.1016/s0960-9822(01)00250-0

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MeSH Terms: Amino Acid Sequence, Centrioles, Cilia, Models, Structural, Molecular Motor Proteins, Molecular Sequence Data, Movement, Organelles, Protein Isoforms, Tubulin