Phytochemicals, pharmacology, clinical application, patents, and products of Amomi fructus.

Sizhuo Suo, Yunfeng Lai, Meng Li, Qirui Song, Jing Cai, Jing Zhao, Qing Yang, Carolina Oi Lam Ung, Hao Hu

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018;119():31-36

PMID: 29802946

Full Text on Elsevier Science View on PubMed

Abstract

Amomi fructus (A. fructus) (Sharen) is a well-known traditional Chinese medicine widely used to treat gastrointestinal diseases. It has high medical and economic values, which have been confirmed both in vitro and in vivo studies. This review highlights the phytochemicals, pharmacology, clinical application, patents, and products of A. fructus. More than 100 phytochemicals have been isolated and identified from A. fructus, mainly including volatile oils, saponins, flavonoids, organic acids, inorganic ingredients, and polysaccharides. The main pharmacology of gastrointestinal protection, anti-inflammatory activity, analgesic activity, antidiarrheal activity, antibacterial activity, anti-microbial activity and hypoglycemic activity have been confirmed. The main clinical applications include functional digestion disorder, gastritis, helicobacter pylori infection in children and treatment of mastitis. There are 23 patents and 405 different drug products of A. fructus.

Address: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao. Electronic address: [email protected].; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao. Electronic address: [email protected].; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao. Electronic address: [email protected].; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao. Electronic address: [email protected].; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao. Electronic address: [email protected].; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao. Electronic address: [email protected].; State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu City, Sichuan Province, China. Electronic address: [email protected].; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao. Electronic address: [email protected].; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao. Electronic address: [email protected].

DOI: 10.1016/j.fct.2018.05.051

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MeSH Terms: Drugs, Chinese Herbal, Humans, Patents as Topic, Phytochemicals, Phytotherapy, Zingiberaceae